Nuclear cardiology plays an important role in clinical assessment and has enormous impact on the management of a variety of cardiovascular diseases. Pediatric patients at different age groups are exposed to a spectrum of radiation dose levels and associated cancer risks different from those of adults in diagnostic nuclear medicine procedures. Therefore, comprehensive radiation dosimetry evaluations for commonly used myocardial perfusion imaging (MPI) and viability radiotracers in target population (children and adults) at different age groups are highly desired.
Using Monte Carlo calculations and biological effects of ionizing radiation VII model, we calculate the S-values for a number of radionuclides (Tl-201, Tc-99m, I-123, C-11, N-13, O-15, F-18, and Rb-82) and estimate the absorbed dose and effective dose for 12 MPI radiotracers in computational models including the newborn, 1-, 5-, 10-, 15-yr-old, and adult male and female computational phantoms.
For most organs, 201Tl produces the highest absorbed dose whereas 82Rb and 15O-water produce the lowest absorbed dose. For the newborn baby and adult patient, the effective dose of 82Rb is 48% and 77% lower than that of 99mTc-tetrofosmin (rest), respectively.
82Rb results in lower effective dose in adults compared to 99mTc-labeled tracers. However, this advantage is less apparent in children. The produced dosimetric databases for various radiotracers used in cardiovascular imaging, using new generation of computational models, can be used for risk-benefit assessment of a spectrum of patient population in clinical nuclear cardiology practice.
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This article by Tianwu Xie, Choonsik Lee, Wesley E. Bolch and Habib Zaidi originally appeared on scitation.aip.org on May 21, 2015 at 06:07PM
